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We are about four years into the compounding of prescriber-authorized Zepbound and B12, and theres no alarming trend of patient-adverse events associated with the compounded drug, Brunner said

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FDA Status BPC-157s FDA status remains not approved for medical use or over-the-counter sale. In April 2026, compounding restrictions were adjusted, but the peptide still cannot be prescribed or sold for human/animal consumption

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When gain-of-function LRRK2 mutants are anchored to mitochondria, it phosphorylates and traps Rab10 nearby (Gomez et al., 2019), causing decreased interaction of Rab10 with OPTN (optineurin), which is an autophagy receptor, therefore impairing mitophagy (Wauters et al., 2020)

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