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Additional information Edited by G Melino Supplementary Information accompanies this paper on Cell Death and Disease website Rights and permissions Cell Death and Disease is an open-access journal published by Nature Publishing Group

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Sigma receptor type 1 gene variation in a group of polish patients with Alzheimers disease and mild cognitive impairment

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Specifically, the biosynthesis of amino acids (37 KOs), was significantly down-represented, including cysteine and methionine metabolism ( metA , metB , metK , mtnN , thrB , cysK , patB and L-serine dehydratase ), the biosynthesis of lysine ( dapA , dapB , dapE , dapH , dapL , argD , patA and lysA ), the metabolism of histidine ( hisA , hisB , hisE , hisH and hisI ), glycine, serine and threonine ( glyA , thrB , thrC and L-serine dehydratase ), alanine, aspartate and glutamate (asnA, asnB and argH), the biosynthesis of phenylalanine, tyrosine and tryptophan ( aroD and aroE ) and the biosynthesis of arginine ( argD and argH )

The sulfhydryl group is the most important functional group of reduced glutathione