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Sulfonamide Analogs To discover new DPP-4 inhibitors, Sharma and Soman developed a series of DPP-4 inhibitors containing various sulfonamide-pyrrolidine/piperidine scaffolds, assessing their binding affinities for the enzyme in comparison to Vildagliptin using in silico research

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GAL is expressed in the gut and the brain with wide distribution throughout the hypothalamus including the PVN, the PFLH, and ARC

In the current study, we conducted a quantitative proteomic analysis to explore the pathways mediating the therapeutic effect of GSH in cerebral ischemia/reperfusion (I/R) model rats