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Therefore, reducing intracellular GSH levels has emerged as a promising strategy to overcome therapeutic resistance and improve treatment efficacy [18]
Furthermore, Gclc -deficient FoB have a block in the mitochondrial electron transport chain (ETC) due to diminished complex I and II activity and thereby accumulate the tricarboxylic acid cycle metabolite succinate
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Carnitine also plays an important role in other diseases associated with depression, like multiple sclerosis (MS), neuromyelitis optica (NMO), and HIV infection
20 GardnerDMichelleLJohnSTerrySWilliamB
Thus, changing the name from NAFLD to MAFLD as well as abandoning the term NASH might perturb the results of many study trials due to the limitation of MAFLD concerning steatohepatitis and hepatic fibrosis
