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Ongoing research investigates its impact on hormonal balance and healthy aging
While semaglutide was initially created to help manage diabetes, doctors soon realized that it could also help with weight loss, even in people who do not have diabetes
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We propose that GLP-1 analogs are superior to DPP-4 inhibitors for managing pasireotide-induced hyperglycemia because GLP-1 analogs, unlike DPP-4 inhibitors, spare pasireotide-induced depletion of endogenous GLP-1 and restore insulin secretion suppressed by pasireotide through GLP-1R-Gs activation, counteracting the SSTRs-Gi axis
Beyond diabetes, GLP-1RAs are also being investigated in conditions such as NASH
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