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This process comprises encapsulating debris in double-membrane autophagosomes, followed by fusion of autophagosomes with lysosomes [248]
Advances in bioinformatics and systems biology facilitate the mapping of intricate protein-protein interactions, the identification of potential biomarkers, and the clarification of molecular mechanisms underlying AD progression
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In AD, for example, inflammation exacerbates amyloid-beta accumulation and tau hyperphosphorylation, thereby worsening neuronal damage
Wu et al., 2006)
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