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Serious risks can include pancreatitis, gallbladder disease, kidney injury related to dehydration, allergic reactions, and worsening diabetic retinopathy in some people with diabetes eye disease
* **Safety:** While FDA-approved for specific groups, it is **not without considerable risks**
Its a complex decision because it adds more side effects in the first-line setting
Compounded semaglutide is not FDA-approved, so its safety and effectiveness are not evaluated by the FDA
Dosing protocol frameworks Dose escalation approach: Clinical trials employed gradual dose escalation to manage gastrointestinal tolerability
For example, one study found that constipation lasted for about 47 days (six weeks) in people taking Ozempic for weight loss
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