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This hormonal cascade works as follows: The hypothalamus releases gonadotropin-releasing hormone (GnRH) GnRH signals the anterior pituitary to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH) LH stimulates the Leydig cells to produce testosterone Rising testosterone feeds back to the hypothalamus and pituitary to regulate production (negative feedback loop) Testosterone is responsible for: Muscle protein synthesis and lean body mass maintenance Bone mineral density Red blood cell production Libido and sexual function Energy, mood, and cognitive function Fat distribution and metabolic health Normal total testosterone in adult men ranges from approximately 300 to 1,000 ng/dL, with levels declining by roughly 1 to 2 percent per year after age 30 (Harman et al., 2001)

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Eliminate Anesthesia Risks : reduce the need for anesthesia (huge for BOAS patients and seniors ) @ Home: can be given at home Stem Cell & PRP Therapy : pair beautifully with PRP , stem cells supplements , and rehab therapy Therapeutic Bully Supplements: supplements , and rehab therapy High Safety : They are relatively safe when used correctly Low-Cost: Inexpensive compared to surgery How Peptides Can Reduce Risks In Bulldogs

doi: 10.1016/j.freeradbiomed.2016.02.028 13