For analysis of cellular uptake of NP4, the 3D spheroids were treated with Cy5.5-labeled NP4 for 12 h
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Gene set enrichment analysis (GSEA) was performed with 1000 permutations to identify enriched biological functions and activated pathways from the molecular signatures database (MSigDB), which included hallmark gene sets, positional gene sets, curated gene sets, motif gene sets, computational gene sets, GO gene sets, oncogenic gene sets, and immunologic gene sets
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Hofstetter WL, Swisher SG , Correa AM, Putnam JB, Jr, Ajani JA, Dolormente M, Francisco R, Komaki RR, Lara A, Martin F, Rice DC, Sarabia AJ, Smythe WR, Vaporciyan AA, Walsh GL, Roth JA
Abstract Candida is an important opportunistic fungal pathogen, especially in biofilm associated infections