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However, more than half of patients do not achieve their A1c goal when treated with an add-on therapy to metformin [Citation88]
Another recent study showed increased calcium accumulation in renal tubular epithelial cells in response to CHAC1 overexpression, which was ameliorated by CHAC1 knockdown ( CHAC1 upregulation was induced by cysteine and methionine deprivation, treatment with erastin and exposure to tunicamycin
Jakubowski, J
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