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Zepbound demonstrated 20.9% mean body weight reduction in SURMOUNT-1 at 15mg surpassing semaglutides 15% benchmark and establishing dual GIP/GLP-1 agonism as the dominant next-generation obesity mechanism

Further study is needed to clarify the best methods of supplementing

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However, the ligand-binding pocket exhibited two unique structural features that were not observed in previously determined GPCRs

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