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If the liquid inside the pen or vial freezes, the peptide molecules are crushed by the formation of ice crystals

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Current management is based on case report outcomes and extrapolation from general neuropathic pain treatment

However, its relatively short plasma half-life of 23 min, due to rapid degradation by dipeptidyl peptidase-4 (DPP-4), has prompted structural modifications to enhance its pharmacological efficacy