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The medication is delivered in injection form once a week
How we grade evidence
Statistical analysis A sample size of 361 participants per treatment arm was calculated to provide 85% power to jointly confirm the superiority of oral semaglutide (14 mg and 7 mg) vs sitagliptin 100 mg and the non-inferiority of oral semaglutide 3 mg vs sitagliptin 100 mg in reducing HbA 1c at week 26 for the trial product estimand
For context, tirzepatide's data come from SURMOUNT (NEJM 2022) and SURMOUNT-OSA (NEJM 2024)
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Similarly, pancreatitisanother labeled risk with semaglutidecan present with persistent severe abdominal pain that may radiate to the back, with or without vomiting, and requires immediate medical attention
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