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Pregnancy and breastfeeding are not recommended

Bovine brain endothelial cells express tight junctions and monoamine oxidase activity in long-term culture

S A Melton, M J Keenan, C E Stanciu, M Hegsted, E M Zablah-Pimentel, C E O'Neil, P Gaynor, A Schaffhauser, K Owen, R D Prisby, L L LaMotte, J M Fernandez

Pharmaceutical manufacturers in the country, including Novo Nordisk, have assured diabetes patients that there is no current impact of COVID-19 on their supply chain

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The features that should prompt assessment are: Severe, sudden pain in the upper right or upper central abdomen Pain radiating to the right shoulder or to the centre of the back Pain that comes in episodes lasting 30 minutes to several hours, particularly after meals Persistent nausea or vomiting beyond the expected GLP-1 side-effect window Fever, chills, or feeling systemically unwell Yellowing of the skin or eyes (jaundice) Dark urine or pale stools The last three suggest more serious complications and warrant urgent medical review