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However, it can also be the result of low B6, low folate, renal failure, or hypothyroidism

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Adequate blood supply is essential to maintain an optimal supply of nutrition, immune cells, and oxygen to the menisci, in exchange for accumulated waste products

Preclinical studies have shown encouraging results

Similarly, although hepatic dysfunction can occur with large niacin doses (1-3 grams daily over months) causing elevated liver enzymes or jaundice, niacinamide at 100 mg is very unlikely to have any adverse effect on the liver