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At the higher weight loss dose of 2.4 mg weekly, semaglutide reduced MACE by 20% (HR 0.80, p less than 0.001) and all-cause mortality by 19%

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GLP-1 treatments may be appropriate for patients who have struggled to lose weight through diet, exercise, or other medications alone especially when factors like insulin resistance, metabolic slowdown, or appetite dysregulation are involved

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This is a benefit exclusion not a prior-authorization denial which means submitting PA paperwork will not change the outcome