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Human glutathione S-transferases- and NAD(P)H:quinone oxidoreductase 1-catalyzed inactivation of reactive quinoneimines of amodiaquine and N-desethylamodiaquine: possible implications for susceptibility to amodiaquine-induced liver toxicity

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If an inherited metabolic problem is suspected, a physician may recommend structured evaluation and treatment for metabolic disorders tailored to the specific diagnosis

R -enantiomer) 59 , which are both highly reactive, labile molecules having covalent bond structures with three consecutive sulfur atoms (see Figure 1a for chemical structures)