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dose may be repeated, as needed, at one-hour intervals to a total maximum of three doses in a 24-hour period and maximum of six doses per week

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doi: 10.1056/NEJMoa2501006 91 ParabPChaudharyPMukhtarSMoradiAKodaliAOkoyeCet al

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The trajectory has been consistent: progressive tightening rather than abrupt prohibition