doi: 10.1007/s13312-022-2663-6 129 ValentiLVarennaMFracanzaniALRossiVFargionSSinigagliaL
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Notably, conventional hemodialysis fails to efficiently clear IS due to its protein-binding property, resulting in persistently elevated concentrations in CKD patients compared to healthy individuals (Ahmed et al., 2013a
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Without proper controls, it is impossible to separate the peptide effect from natural healing (remembering that 85% of acute herniations resolve on their own), placebo effects, concurrent treatments, and time