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Recent studies show that Protein Kinase C beta II (PKCII) senses initial lipid peroxidation events, phosphorylates ACSL4, and drives the activation of ACSL4, promoting PUFA incorporation into phospholipids and subsequent cell death [34]

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Compared to the control AB(WT) fish, the LMNA (WT) and the LMNA mutant transgenic fish (except LMNA (W520G) because no fish survived after F0) showed significantly higher levels of LMNA mRNA expression (Fig