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88 Mfn2-mediated mitochondrial fusion supports mitophagy, and its loss impairs clearance, contributing to sarcopenia
Chen C, Wang D, Yu Y, Zhao T, Min N, Wu Y, et al
Klein H, et al
Day and colleagues were the first group to use a series of modifications to the C-terminal portion of the glucagon sequence to increase GLP-1R potency, combined with PEGylation to generate two PEGylated peptides with adequate co-agonist properties, one unbalanced towards GLP-1R, and the other a near-balanced agonist at both GLP-1R and GCGR
These risks necessitate a careful assessment of patient history and ongoing monitoring during treatment
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