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It is unknown whether OZEMPIC causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans as the human relevance of semaglutide-induced rodent thyroid Ccell tumors has not been determined
Animal studies have shown that Semaglutide stopped the progression of plaque formation
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However, published case reports and a 2024 retrospective cohort in Thyroid (N=112 patients on stable levothyroxine who started semaglutide) found that 28% required a TSH recheck within 6 months because of new hypothyroid symptoms or rising TSH, compared with 9% in a matched control group not starting GLP-1 therapy [7]