Mounjaro (Tirzepatide) Dual action: targets both GLP-1 and GIP receptors Strong appetite suppression & improved blood sugar control Clinical trials show average body weight loss up to 22.5% over 72 weeks Wegovy (Semaglutide) Targets GLP-1 receptors only Licensed in the UK for obesity and cardiovascular protection STEP trials show 1521% body weight loss A new 7.2mg dose is expected in late 2025, with results potentially matching Mounjaro Both treatments are once-weekly injections, prescribed alongside healthy diet and lifestyle changes
Serious risks can include pancreatitis, gallbladder disease, and kidney injury, and these medications carry a boxed warning for the risk of thyroid C-cell tumors
Compounded GLP-1s serve a limited role when they are used to accommodate specific patient needs, such as an allergy to an ingredient or difficulty swallowing a pill, that cannot be met by an FDA-approved drug
You are encouraged to report negative side effects of prescription products: Contact FDA MedWatch at 1-800-FDA-1088 or visit www.fda.gov/medwatch This information is not comprehensive
Hormone Therapy Can HelpBut Its Only Part of the Equation Hormone therapy (HT) can attenuate visceral fat gain by up to 60% , improve insulin sensitivity, and support muscle mass
However, if you feel persistently dizzy, faint, or unusually weak during GLP-1 therapy, notify your healthcare provider immediately