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A fixed-effect model was used for meta-analysis where heterogeneity was less than 50%
79 Insulin has also been shown to have anabolic effects on bone by stimulating osteoblasts whilst suppressing osteoclast function
The reduction in visceral fat, which is strongly associated with insulin resistance, provides additional metabolic benefits
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Vijayashankar, M
They noted that these findings aligned with prior pooled evaluations of the Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes (SUSTAIN) and Peptide Innovation for Early Diabetes Treatment (PIONEER) programs, and that eye examinationsimplemented more consistently in later trialshelped strengthen confidence in the findings
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