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Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of medications originally developed for managing type 2 diabetes mellitus and, more recently, some have been approved for weight management

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We propose that the increase in circulating glucagon observed following genetic/pharmacological inactivation of glucagon signalling in mice and in people with type 2 diabetes reflects the removal of GLP-1(936)s glucagonostatic action

Like other GLP-1-related medications, Mounjaro affects appetite, blood sugar regulation, insulin response, and gastric emptying, which may help some patients lose weight