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67,75 Interestingly, a level of uric acid that is either too high or too low disrupts the delicate balance of oxidative stress regulation and may lead to excessive oxidative damage or impaired antioxidant defense
PubMed laboratory research record [PMID: 20078251] PubMed record related to this compound for laboratory literature review
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It inhibits NOTCH1 signaling by using its GCT activity to cleave a -glutamyl-cysteine bond at glutamate 1669 of the immature NOTCH receptor, thereby preventing the essential S1 cleavage and subsequent activation ( FIGURE 6 The physiological importance of this mechanism is underscored by severe developmental phenotypes upon its disruption
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