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In an embryofetal development study in pregnant cynomolgus monkeys, subcutaneous doses of 0.015, 0.075 and 0.15 mg/kg twice weekly (1.9-, 9.9- and 29-fold the MRHD) were administered throughout organogenesis, from Gestation Day 16 to 50
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E.SimpsonR
Metabolic syndrome is characterised by insulin resistance and consequent hyperinsulinaemia - hyperinsulinaemia is associated with increased appetite and consequent weight gain which then compounds the insulin resistance
Based on the dramatic fat reduction (up to 82.4%) and enzyme normalization (70-80%), researchers estimate a high probability of NASH resolution, but this needs confirmation in a dedicated Phase 3 trial with biopsy endpoints (expected 2027-2030)
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