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The NNMT enzyme uses a methyl group to metabolize excess nicotinamide into metabolites that are eventually excreted in the urine

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Bone, 2013

Audrey Falconi

However, in people with T2D and MASLD, 24 weeks of efinopegdutide 10 mg reduced liver fat content by 72.7% compared to 42.3% reduction with semaglutide 1 mg despite similar WL achieved with both interventions [79]