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For patients with severe B12 deficiency, we may recommend an initial loading phase of daily or weekly injections to quickly restore B12 levels
However, patients with sulfa allergy should not take this injection
There was a gain in body weight during both periods
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It will be interesting to explore how the additional histone H3 methyl changes we observed with B 12 supplementation, as well as yet-unidentified changes in methylation of DNA, other proteins, or lipids may contribute to the improved reprogramming efficiency achieved by vitamin B 12
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