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You should only increase your dose (titrate) when: You have successfully tolerated the current dose for at least 1-2 weeks

Compared to healthy controls, SCD patients have significantly lower erythrocyte GSH and cysteine concentrations 12 and a faster rate of GSH synthesis, suggesting that the endogenous cysteine supply is insufficient to meet all anabolic demands

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Any failure in control can result in the permanent irreparable damage (scrapping) of the resin