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Patients should be advised to eat smaller, more frequent meals and avoid high-fat foods, which can exacerbate nausea
If they persist strongly throughout the full four weeks, that is useful information for deciding whether to extend this phase before escalating further
Tirzepatide can also cause mild dehydration through its effects on gastric function
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Finally, a discussion emerged regarding a specific population that may significantly benefit from combined therapy: individuals with obesity and T2D and high or very high cardiovascular risk or obesity
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