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CDCA-mediated FXR stimulation occurs in ileal enterocytes and hepatocytes and mediates the expression of fibroblast growth factor 15/19 (FGF 15/19) and small heterodimer protein (SHP) (Sonne, 2021)

Regarding the mechanism by which GLP-1RAs are taken up into the brain, it has been reported that GLP-1RAs do not cross the blood-brain barrier through endothelial cells [5]

Key GLP1 therapies are integrated into national insurance schemes, and the countrys aging population underscores its strategic importance in diabetes and obesity management

There is no evidence-based universal waiting period after GLP-1associated shedding

doi: 10.1111/dom.14280 180 JensterleMKovacJAndrejVFerjanSBattelinoSBattelinoTet al