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More serious but less common adverse effects include: Pancreatitis : Patients should seek immediate medical attention if experiencing severe, persistent abdominal pain radiating to the back Gallbladder disease : Rapid weight loss can increase the risk of gallstones Hypoglycaemia : Particularly when used alongside other diabetes medications such as sulphonylureas or insulin Diabetic retinopathy complications : Rapid improvement in blood glucose control may temporarily worsen retinopathy in susceptible individuals Acute kidney injury : Usually in the context of dehydration from vomiting or diarrhoea Animal studies have shown an increased incidence of thyroid C-cell tumours with semaglutide, though the human relevance of this finding is unknown
[19]Zulfiqar U, Farooq M, et al
Figure 5 Adverse effects associated with GLP-1 agonist and control Nausea The findings indicate that, among the included studies, ROSE-010 (100 g) is substantially linked to an increased risk of nausea
Weeks 48: Gradual improvements in metabolic rate, fat oxidation (particularly visceral fat), and cellular repair
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