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We calculate optimistic and pessimistic scenarios by flexing these key assumptions to plausible higher and lower values

For most of these agents, therefore, by the time you discount those future events back in terms of quality-adjusted life-years, and also in terms of the economic value of those costs, it's challenging for new products to be cost-effective

J Cell Physiol 217(2):377387 Liangpunsakul S, Chalasani N (2005) Unexplained elevations in alanine aminotransferase in individuals with the metabolic syndrome: results from the third National Health and Nutrition Survey (NHANES III)