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Journal of Agricultural and Food Chemistry, 62 , 9499-9506

These findings are consistent with Wang et al

Adult male C3H/HeJ mice at 12- to 17-weeks of age were treated with PBS or leptin for 9-days using an implanted osmotic minipump that dispensed into the subcutaneous space (SC, PBS N = 5, leptin N = 5) or directly to the brain through an intracerebroventricular cannula (ICV, PBS N = 10, 10 ng/hr leptin N = 11, 100 ng/hr leptin N = 6 for plasma

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Liver-specific expression of transcriptionally active SREBP-1c is associated with fatty liver and increased visceral fat mass

Reported signs and symptoms: Reduced level of consciousness (60%)