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Hum Genet 2002
Oral formulations are expanding
Moreover, the upregulation of LDLR gene expression in cells treated with GLP-1RAs occurs through both SREBP-2-dependent and SREBP-2-independent pathways
Long-term data beyond trial periods is still being collected
Women of childbearing potential should be counseled regularly regarding the relative risks and benefits of valproate use during pregnancy
Betul Ibis and colleagues, used the TriNetX database to compare 217,302 diabetes patients on GLP-1 medications with 217,302 matched patients on DPP-4 inhibitors. Patients on GLP-1s had a significantly lower risk of developing rheumatoid arthritis (HR = 0.87, p = 0.026), gout, and osteoarthritis within one year
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