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It contains a cyanide molecule, which is replaced by a methyl or adenosyl group in the body, allowing it to convert into an active form of B12

For most patients, the constipation is worst during the first 3 months of treatment or during dosage increases (e.g., moving from 5mg to 7.5mg )

If morning dosing is logistically impossible

The age range of the study population was 2392 years old

The vitamin B12 iv dose and how its given can be adjusted to fit each persons needs

Look for lot-specific, third-party HPLC purity (typically reported in the high-90s) and mass-spectrometry identity confirmation on the Certificate of Analysis for the exact lot received