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As GLP-1R agonists continue to shape the future of obesity treatment, studies like this one provide a deeper understanding of the biological complexity underlying their successand their limitations

A broken seal or signs of leakage Check that the cap and stopper are intact, with no cracks, leaks, or liquid pooled around the top, since a broken seal can mean contamination

The evaluation itself is where the real work happens

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Until then, scientists thought drug use and drug-specific cues triggered an excessive surge of dopamine, the so-called pleasure hormone, which drives craving, addiction and relapse

doi: 10.1056/NEJMoa2032183