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Cartilage & Joint Protection Because DSIP is often studied for sleep regulation , it is natural to compare it with melatonin , the most widely used sleep supplement: AOD-9604 demonstrated chondroprotective effects in models of cartilage degradation. May reduce proteoglycan loss and support collagen maintenance

The compound is one of the most-studied peptides in preclinical regenerative-research literature, with more than 100 published animal studies covering gastric and intestinal cytoprotection, tendon and ligament repair, angiogenic pathway activity, and central nervous system models

Figure 1 In a subsequent study, the same authors reported a dual effect of H 2 O 2 on cell proliferation, depending on dose used (67)