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Given the above and current knowledge, a clinically significant DDI between GLP1RAs and COCs is probably not expected, and there is no recommendation in any GLP1RA prescription sheet for dose adjustment of COCs in this context

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This would be because Medicare Part D has been prohibited by statute from covering drugs for weight loss

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All analyses were two-sided and performed using R software (Version 4.0.2) with the TwosampleMR and MR-PRESSO R packages

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