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Clinically, small trials of topical GHK-Cu creams have measured significant increases in skin density and elasticity after several weeks of use

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The evolutionary theory was that naevi progress from junctional to compound and then intradermal, which is now thought not to be case for all such lesions Dermoscopy has given rise to a new classification of melanocytic naevi based on their pigment pattern, which in common moles can be: Predominantly reticular (ie a pigment network) - these are acquired naevi , which have melanocytes at the dermoepidermal junction Globular / cobblestone - nests of melanocytes found in the dermis (ie dermal naevi )