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However, these mainstream therapies face critical limitations including the rapid emergence of drug resistance, FKS1/FKS2 gene mutations reducing -1,3-glucan synthase affinity, Targeted enzyme (Erg11p) modification, overexpression of efflux pumps (CDR1, MDR1), and upregulation of the ergosterol pathway mediate azole resistance (Pristov and Ghannoum, 2019)

The MHRA does not assess the efficacy of food supplements, meaning they are not subject to the same rigorous testing and approval processes as pharmaceutical products

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Research by Pickart and Margolina (2018) in the International Journal of Molecular Sciences showed that GHK-Cu modulates approximately 31% of human gene expression, activating 59% of affected genes and suppressing 41%

Therefore, a comparative analysis of the acceptance level of Spirulina in different cultural and regional markets in future research will enable a more comprehensive assessment of its potential (132)

So if theyre not supplementing with B12 and preferably active forms of B12, then they could definitely have this problem