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J Neurosci 26(30):78707874 Hermes G, Li N, Duman C, Duman R (2011) Post-weaning chronic social isolation produces profound behavioral dysregulation with decreases in prefrontal cortex synaptic-associated protein expression in female rats

When the NF-B pathway is activated, it triggers production of pro-inflammatory proteins downstream, such as tumor necrosis factor- (TNF-), which in turn causes inflammatory responses and pain

Patients often feel results quickly, more energy, clearer focus, and improved motivation