The useful analytical framework is to ask: what is the net present value of revenues the innovator can defend after patent expiry, given realistic lifecycle management success rates, biosimilar/generic competition timelines, and payer formulary dynamics
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Glucagon-like peptide-1 receptor agonists and risk for gastroesophageal reflux disease in patients with type 2 diabetes: a population-based cohort study
Figure 1b visualizes these data together with four activity regions representing the possible potency measurements at hGCG and hGLP-1 for dual-agonist peptides