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STEP-1: Semaglutide 2,4 mg, the standard since 2021 The STEP-1 trial (Wilding et al., NEJM 2021, PMID 33567185) randomized 1,961 overweight or obese adults (BMI 30 or BMI 27 with comorbidities) without diabetes to semaglutide 2,4 mg/week or placebo, with lifestyle interventions administered concurrently in both arms
Irregular Menstrual Cycles: Irregular or absent menstrual cycles can be a symptom of PCOS
Although the mean estimated glomerular filtration rate (eGFR) remained above 60 mL/min/1.73 m 2 (with an average eGFR of approximately 73 mL/min/1.73 m 2 ), alanine transaminase (ALT) levels were mildly elevated, surpassing 30 IU/L (with an average ALT of approximately 33 IU/L) (Table 2)
While weight loss wasnt the original goal, extensive research has confirmed that semaglutide and GLP-1 medications can effectively support weight management