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Clinical trials show tirzepatide generally leads to greater average weight loss than semaglutide
It drives weight loss through appetite modulation rather than metabolic acceleration
Key exclusion criteria were diabetes, a glycated hemoglobin level of 48 mmol per mole (6.5%) or greater, a history of chronic pancreatitis, acute pancreatitis within 180 days before enrollment, previous surgical obesity treatment, and use of antiobesity medication within 90 days before enrollment
5 mg vial + 1 mL bacteriostatic water = 5 mg/mL 2 mg dose = 0.4 mL (40 units on a standard insulin syringe) 2.5 mg dose = 0.5 mL (50 units) 5 mg vial + 2 mL bacteriostatic water = 2.5 mg/mL 2 mg dose = 0.8 mL (80 units) 2.5 mg dose = 1 mL (100 units, full syringe) 10 mg vial + 2 mL bacteriostatic water = 5 mg/mL 2 mg dose = 0.4 mL (40 units) 2.5 mg dose = 0.5 mL (50 units) 5 mg dose = 1.0 mL (100 units) Most people stick with the 1 mL per 5 mg ratio because the numbers come out clean and easy to draw
Al Koborssy, D
