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While preparing this manuscript for submission, a study based exclusively in in vitro assays was published showing that the addition of 25 M BSO or the use of tools to delete GCLC inhibits the growth of Burkitt lymphoma cell lines under 2D culture conditions [42], seemingly suggesting a comparable susceptibility to glutathione starvation between TICs and differentiated tumor cells

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Compared with chemotherapy alone, the phase III ToGA clinical trial demonstrated that adding trastuzumab to standard fluoropyrimidine plus platinum-based chemotherapy significantly improved OS (median OS: 13.8 months versus 11.1 months, HR = 0.74, P = 0.0046)

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Thus, it seemed interesting to look into the possible protective effect of this molecule on the effects of strenuous exercise, in which free radicals seem to be involved

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