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The treatment policy estimand evaluated the effect of treatment regardless of treatment discontinuation or initiation of rescue medication [60], comparable to an intention-to-treat approach
Euglycemic diabetic ketoacidosis is another concern that may delay initiation or result in early discontinuation of SGLT2i therapy [4, 19]
Improvements in HDL functionality, rather than absolute HDL levels, may contribute to cardiovascular benefits through enhanced reverse cholesterol transport
NICE guideline NG69 recommends guided self-help programmes based on cognitive behavioural therapy (CBT) principles as first-line treatment for adults with binge eating disorder
95% CI, 0.77
People may suffer embarrassment and social anxiety, trouble eating that leads to weight loss, nausea, sleep loss, and chronic fatigue
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