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PloS Pathog (2020) 16:e1008470
Washout period: After discontinuation, approximately 5 weeks (5 half-lives) are required for substantial clearance
Wegovy is now indicated for reduction of cardiovascular event, which means some payers that previously did not cover the drug for obesity now cover it for cardiovascular disease
Use only with physician supervision
Switching between medications If one medication becomes unaffordable but another remains accessible, switching may be viable
This revealed an interaction between the metabolite and mitochondrial trifunctional protein- (MTP), which is known to regulate fatty acid oxidation (FAO) (23)
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