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BMI of 30 or higher: Qualifies if they also have a diagnosis like heart failure (with preserved ejection fraction), uncontrolled high blood pressure, or chronic kidney disease (Stage 3a or higher)

doi: 10.1016/j.ijnurstu.2008.12.015 31 CuzzolinL.Francini-PesentiF.VerlatoG.JoppiM.BaldelliP.BenoniG

doi: 10.1016/j.phrs.2022.106320 37 YustaBBaggioLLKoehlerJHollandDCaoXPinnellLJet al

Using sterile water (which has no preservative) means your vial is susceptible to bacterial growth the moment you make that first puncture

Patients should be told this directly, and it should appear in the consent conversation

These higher doses are not available in all regions, and suitability depends on individual response and clinical advice